the above mentioned information is furnished for normal informational and educational functions only. Individual programs may vary and formulary data modifications. Call the relevant strategy supplier for quite possibly the most recent information and facts.
considering the fact that a non-wellbeing professional are going to be obliged to recognize episodes appropriate for therapy, make the choice to administer remedy on that identification, administer the drug, keep track of the affected person, and evaluate the adequacy in the reaction to treatment method; a major component with the prescribing course of action will involve the necessary instruction of the individual
nifedipine will enhance the degree or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use warning/observe.
The continued usage of benzodiazepines, which include VALIUM, could bring on clinically sizeable physical dependence. The hazards of dependence and withdrawal enhance with for a longer time treatment length and better everyday dose. Abrupt discontinuation or rapid dosage reduction of VALIUM soon after continued use may precipitate acute withdrawal reactions, which may be lifetime-threatening.
fludrocortisone will decrease the level or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use warning/observe.
fluconazole will enhance the level or influence of check here diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
people at an increased danger of withdrawal adverse reactions soon after benzodiazepine discontinuation or immediate dosage reduction consist of people who consider increased dosages, and all those who have experienced more time durations of use.
buprenorphine subdermal implant and diazepam both equally increase sedation. prevent or Use Alternate Drug. Restrict use to individuals for whom different treatment method selections are insufficient
Avoid or substitute another drug for these medicines when attainable. Evaluate for loss of therapeutic influence if medication need to be coadministered. modify dose In keeping with prescribing information and facts if necessary.
diazepam will improve the stage or outcome of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. keep away from or Use Alternate Drug. If coadministration of lonafarnib (a delicate CYP3A substrate) with weak CYP3A inhibitors is unavoidable, minimize to, or carry on lonafarnib at setting up dose.
darifenacin will increase the degree or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use warning/Monitor.
Diazepam is FDA authorized with the administration of anxiousness Ailments, quick-time period reduction of nervousness signs, spasticity connected to upper motor neuron Issues, adjunct therapy for muscle mass spasms, preoperative panic aid, management of specified refractory epilepsy individuals, and adjunct in intense recurrent convulsive seizures, and an adjunct in position epilepticus.
dronedarone will raise the degree or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use warning/observe.
Use warning/observe. Ethinyl estradiol could inhibit the clearance of benzodiazepines that undergo oxidation, therefore raising serum concentrations of concomitantly administered benzodiazepines.